Synchronized brain network underlying postural tremor in Wilson's disease
Identifieur interne : 003159 ( Main/Exploration ); précédent : 003158; suivant : 003160Synchronized brain network underlying postural tremor in Wilson's disease
Auteurs : Martin Südmeyer [Allemagne] ; Bettina Pollok [Allemagne] ; Harald Hefter [Allemagne] ; Joachim Gross [Allemagne] ; Markus Butz [Allemagne] ; Lars Wojtecki [Allemagne] ; Lars Timmermann [Allemagne] ; Alfons Schnitzler [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cuivre.
English descriptors
- KwdEn :
- Adult, Brain (pathology), Brain (physiopathology), Brain Mapping, Coherence, Copper, Electroencephalography (methods), Electromyography (methods), Encephalon, Evoked Potentials, Motor (physiology), Evoked Potentials, Motor (radiation effects), Hepatolenticular Degeneration (complications), Humans, Magnetic Resonance Imaging (methods), Magnetoencephalography, Male, Middle Aged, Muscle, Skeletal (physiopathology), Nerve Net (physiopathology), Nervous system diseases, Nuclear magnetic resonance imaging, Posture, Tremor, Tremor (etiology), Wilson disease, Wilson's disease, coherence, magnetic resonance imaging, magnetoencephalography, tremor.
- MESH :
- complications : Hepatolenticular Degeneration.
- etiology : Tremor.
- methods : Electroencephalography, Electromyography, Magnetic Resonance Imaging.
- pathology : Brain.
- physiology : Evoked Potentials, Motor.
- physiopathology : Brain, Muscle, Skeletal, Nerve Net.
- radiation effects : Evoked Potentials, Motor.
- Adult, Brain Mapping, Humans, Male, Middle Aged, Posture.
Abstract
Common neurological manifestation of Wilson's disease (WD) is a postural tremor of the upper extremities. Recently, the primary sensorimotor cortex (S1/M1) has been shown to be involved in WD postural tremor generation. However, neuropathological changes in WD are mostly observed in subcortical structures. We therefore aimed to investigate whether S1/M1 may be functionally interconnected with other brain areas. In five WD patients, we used magnetoencephalography and surface electromyography (EMG) to record simultaneously cerebral neuronal activity and muscular activity during sustained posture of the right forearm. As demonstrated previously, the strongest coupling to tremor EMG was observed in the contralateral S1/M1. This area was taken as reference in order to identify and localize cerebro–cerebral coherence at tremor frequency and its first harmonic. The analysis revealed significant coherence within an oscillatory network including S1/M1, higher cortical motor areas (premotor cortex, PM; supplementary motor area, SMA), posterior parietal cortex (PPC) and thalamus contralateral as well as the cerebellum ipsilateral to the tremor forearm. Flow of information was mainly of bidirectional nature. Taken together, our results indicate that WD postural tremor is generated within a synchronized cerebello–thalamo–cortical network, comprising S1/M1, higher cortical motor areas (SMA, PM), and PPC. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21104
Affiliations:
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Recently, the primary sensorimotor cortex (S1/M1) has been shown to be involved in WD postural tremor generation. However, neuropathological changes in WD are mostly observed in subcortical structures. We therefore aimed to investigate whether S1/M1 may be functionally interconnected with other brain areas. In five WD patients, we used magnetoencephalography and surface electromyography (EMG) to record simultaneously cerebral neuronal activity and muscular activity during sustained posture of the right forearm. As demonstrated previously, the strongest coupling to tremor EMG was observed in the contralateral S1/M1. This area was taken as reference in order to identify and localize cerebro–cerebral coherence at tremor frequency and its first harmonic. The analysis revealed significant coherence within an oscillatory network including S1/M1, higher cortical motor areas (premotor cortex, PM; supplementary motor area, SMA), posterior parietal cortex (PPC) and thalamus contralateral as well as the cerebellum ipsilateral to the tremor forearm. Flow of information was mainly of bidirectional nature. Taken together, our results indicate that WD postural tremor is generated within a synchronized cerebello–thalamo–cortical network, comprising S1/M1, higher cortical motor areas (SMA, PM), and PPC. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name></noRegion><name sortKey="Butz, Markus" sort="Butz, Markus" uniqKey="Butz M" first="Markus" last="Butz">Markus Butz</name><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name><name sortKey="Hefter, Harald" sort="Hefter, Harald" uniqKey="Hefter H" first="Harald" last="Hefter">Harald Hefter</name><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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